About Us

Crystallise Ltd was established in 2012. Our experience of clinical medicine, health informatics, programming and consultancy in healthcare, pharmaceutical, finance and other public sectors gave us a unique perspective on the benefits that arise from applying the learnings and approaches of one discipline to the problems faced by another industry.

The aim of Crystallise is to provide an innovative approach to processing information, using software tools to automate processes that are slower and less accurate when done by humans. Our approach provides clients with greater transparency and scope than they could find for the same budget elsewhere. We work with a network of experts and organisations that help us support clients efficiently and effectively, and are proud of our flexible and ingenious way of solving their problems.

See our publication list here.


Our medical and pharmaceutical experience

The Crystallise team has more than 50 years’ combined experience in providing services for healthcare and pharmaceutical clients.

Qualified doctors provide medical insight into mortality trends and their drivers. Clinical understanding means new medical developments are rapidly evaluated in the context of current practice and unmet needs.

Staff experienced in systematic reviews and evidence synthesis for pharmaceutical and health technology assessment clients ensure reports are based on systematic evaluation of the evidence.

Staff skilled in writing for a non-medical audience mean the evidence is synthesised into easily understood reports.

Pragmatic and systematic evidence synthesis skills mean bespoke reports can be adapted to your requirements, deadlines and budget.

Our modelling experience

The Crystallise team has more than 30 years’ combined experience in modelling data for healthcare, pharmaceutical and financial clients.

Data identification and cleansing skills and systematic review expertise ensure reliable and unbiased model inputs.

Smoothing and statistical expertise means data can be presented at different levels of granularity without losing validity or confusing outputs with unnecessary “noise”.

Staff with combined medical, financial and modelling skills mean model outputs make sense for clinicians, actuaries, financial advisors and healthcare payers or providers.

Mortality models allow you flexibility in choosing outputs, including central mortality, curves of death, life expectancy and years of life lost – overall and by cause of death.

Our programming experience

The Crystallise team has more than 45 years’ combined experience in computer programming and software development for healthcare and financial clients.

Experienced programmers translate mortality models into easy-to-use software.

Medical input into graphic design provides clear representation of complex medical concepts.

Our financial sector experience

The Crystallise team has more than 10 years of collective experience on interpreting mortality data for financial clients.

Staff with medical expertise rapidly identify significant medical advances that will affect mortality improvement.

The team

Dr Chris Martin (Director and Head of Modelling)

Chris is a former General Practitioner and Health Informatician with an MSc and PhD from the Centre for Health Informatics and Multi-professional Education at University College, London. He has specialised in cause of death and risk factors-based mortality and longevity modelling to support health care decision-making at the clinical and policy level for over twenty years, and has worked in the pensions and insurance industry since 2008.

He is a Fellow and former Council member of the Royal College of General Practitioners and is a former chairman of the Essex Faculty of the RCGP and the Essex Primary Care Research Network.

Chris is the co-founder of Crystallise Ltd., which provides medical modelling advice and software to the finance, healthcare and pharmaceutical industries. He has contributed to Longevity Science Panel reports The biology of ageing and Life expectancy: is the socioeconomic gap narrowing? At Crystallise, Chris leads the modelling team on developing a range of mortality, infectious disease and clinical trial simulation models.

Dr Alison Martin (Director and Head of Reviews)

Alison has experience as a junior hospital doctor working in general medicine, nephrology, medical oncology, cardiology, general surgery and urology. However, most of her career has been spent working in the field of evidence-based medicine for organisations including Drug and Therapeutics Bulletin, the BMJ Group, Matrix Knowledge Group, Evidera and Crystallise. At the BMJ Group she was a Senior Clinical Editor on evidence-based publications for clinicians and other health care staff and researchers, including BMJ Clinical Evidence, BMJ Best Practice and BMJ Action Sets.

During her time at Matrix, Alison led the team that delivered evidence reviews for a wide range of clients including NICE, the European Centre for Disease Prevention and Control, the Health Foundation, the Ministry of Justice and the Home Office. At Evidera, she led a series of systematic reviews and HTA submissions for pharmaceutical companies. At Crystallise, Alison has led the development of the heoro.com database and the Evidence Map deliverable. She has helped with content generation and editing of reports for the Legal and General Longevity Science Panel and conducted targeted and systematic reviews for pharmaceutical clients, including HTA submissions to NICE.

Dr Cassandra Springate (Reviews consultant)

Cassie has a BSc and MSc in Psychology from the University of Nottingham, and a PhD in Psychology from City, University of London. She has experience working as a research assistant on a 3-year ESRC project investigating false memory and analogical reasoning in children, and more recently as a research associate investigating memory reconsolidation and learning. Cassie has also worked as a Lecturer in Psychology for Richmond University.

Cassie has 5 years of experience of conducting literature reviews and academic writing. She is first author on a 3* publication in Emotion, and another under review. She has conducted several independent reviews for her degree dissertations. She also has experience conducting literature reviews in her roles as a research assistant, and through the completion of her PhD thesis. At Crystallise, Cassie has worked on systematic and targeted reviews including HTA submissions and Evidence Map generation for Pharmaceutical clients. Cassie is also leading on the development of synthetic samples for clinical trial simulation. Cassie has developed programs in VBA to increase company productivity and has also supported development of mortality modelling.

Alexandra Furber (Senior Researcher)

Alex has a BSc in Biomedical Science from Royal Holloway University London and an MSc in Biomedical Science specialising in microbiology from Kingston University.

As part of her MSc, Alex studied research techniques and scientific communication, including systematic review methodology. At Crystallise, Alex has worked on systematic and targeted reviews and Evidence Map generation for Pharmaceutical clients and is leading on the development of an infectious disease model.

Dr William Letton (Research and Development Consultant)

William has a BA in Biological Sciences from Cambridge University and a PhD in Stem Cell and Developmental Biology from University College London. For his doctoral research project, he studied the interaction of circadian and cell cycle rhythms as well as the role of mutations in the gene Bestrophin-1 in ADVIRC disease.

At Crystallise, he is expanding Boolean and probabilistic search methodologies for systematic reviews and developing tools for live monitoring of public data trends.

Dr Louisa Rutherford (Senior Clinical Researcher)

Louisa has a degree in Biological Sciences from the University of Edinburgh and went on to study medicine at King’s College London. She gained experience as a junior doctor in general medicine, general surgery, emergency medicine, oncology and pathology. She went on to work for the BMJ Group where she worked within the Evidence Centre on the evidence-based publication BMJ Best Practice. She was responsible for all stages of content development of healthcare articles for digital platforms.

Louisa also worked for BMJ Informatica/Health Analytics where she was involved in the creation and editing of new and existing digital products, intelligence tools and software that provided real time guidance, assistance in population screening, diagnosis and treatment for GPs. She had particular involvement in the patient safety aspect and testing of these tools. At Crystallise, Louisa works with the reviews team, assisting with screening, data extraction and report writing.


Holly Gould (Researcher)

Holly completed a BSc in Neuroscience from the University of Sussex and went on to do a MSc in Public Health at Brighton and Sussex Medical School. During both her university courses she completed modules on medical research methods and statistics. For her masters dissertation, Holly completed a systematic review titled: “The Experience of Dementia Diagnosis in Individuals from Black and Minority Ethnic Groups: A Systematic Review and Qualitative synthesis”.   

Hannah Rice (Researcher)

Hannah has a BSc in Biomedical Science from the University of Hertfordshire. As part of her degree, she studied bioscience research methods and wrote a literature review on how dietary supplements effect cognitive function.

Shannon Connolly (Analyst)

Shannon has a BSc in Sport and Exercise Science from the University of Bath and an MSc in Data Science and Analytics from Brunel University London. As part of her MSc, Shannon developed a pandemic model of Europe using Petri Nets to simulate the spread of COVID-19 investigating various intervention measures.

During her BSc, Shannon helped on an exercise nutrition study investigating dietary carbohydrate periodisation on iron regulation and immune function in elite triathletes, and her final year dissertation examined the effect of certain psychological moderators on stress and injury risk in university athletes.

At Crystallise, Shannon has modelled national data to parameterise mortality models. She is also working on developing software tools to facilitate data extraction.

Kalliopi Roussi (Proof-reader / Editor)


Kelly has a BSc in Biology from the University of Athens, a MSc by research in Reproductive Sciences from the University of Edinburgh and a PhD in Medical Sciences from the Hull York Medical School. Her PhD dissertation focused on the impact of hyperglycaemia on early embryo environment and development.

Kelly has previous experience in conducting systematic literature reviews and meta-analyses, which she gained during her time as a Clinical Evidence Specialist for Smith and Nephew. The results of one of the systematic reviews performed as part of this position were published in Knee Surgery, Sports Traumatology, Arthroscopy in 2020.

At Crystallise, Kelly is responsible for proofreading and editing components of systematic literature reviews to ensure the accuracy of the information presented.

Nicola Clarke (Researcher)

Nicola has a BSc in Psychology from Leeds Beckett University and an MSc in Health Psychology from Staffordshire University. As part of her BSc, Nicola completed a research assistant placement working within the Stigmatised Sexualities and Sexual Harm Research Group which involved assisting on a literature review to inform the production of infographics to challenge commonly held myths surrounding sexual violence and abuse. Throughout university she has specialised in cognitive, experimental psychology. Her undergraduate research project investigated the effect of emotion on visual perception and attention and her postgraduate research project used eyetracking to investigate health priming, visual attention and food choice. 

Lauren Moubarak (Researcher)

Lauren is a qualified pharmacist. She completed her training year after obtaining a BSc in Pharmacology and MSc in Pharmacy from Medway School of Pharmacy. Her MSc focused on the role of different potassium channels in circadian rhythm regulation and the effect that misalignment has on several diseases, such as cancer, depression and neurodegeneration.

As part of her studies, Lauren completed several modules on research techniques, study methodology and evidence-based medicine. She also completed a chemistry elective looking at different techniques used to identify drug targets and how to optimise receptor interaction.

Lauren completed her pre-registration pharmacist training year in August 2020 and is now a qualified pharmacist. She has completed placements in epilepsy clinical units, cancer research and worked in both hospital and community pharmacy. She has also worked as the trainee representative in North London for the past year and attended several research events. Her area of interest lies within clinical research and pharmaceutics.

Christian Todaro (Researcher)

Christian has a BSc and MSc in Cell Biology and Microbiology from the University of Sheffield including 2 years lab experience in areas ranging from immunotherapy to RNA and protein characterisation.

In his final year he studied the effects of mutations in the regulatory regions of the genome, specifically in relation to T-cell acute lymphoblastic leukaemia.

Sue Martin (Business Manager)

With decades of experience in accountancy, book-keeping, business administration and recruitment, including running her own staffing agency and office services company for many years, Sue is now responsible for business administration at Crystallise, and finds and hires the awesome talent required to keep Crystallise over-delivering on the diverse range of projects it takes on. 

If you are interested in working for Crystallise she is the person to get in touch with, or if you want to know more about how Crystallise can help solve your modelling and informatics problems she can put you in touch with the right people. 

Bikramaditya Ghosh (Contracting researcher)

Bikram completed a Bachelor in Dental Surgery (BDS) from KIIT University, India and then gained a Masters in Public Health (MPH) from the University of Sheffield, UK with a major in systematic reviews. His dissertation was on “Early diagnosis of Oral cancer and oral pre-malignancies in Asian population: Systematic review”.

Bikram joined Crystallise as a Researcher in 2019. He has two years of experience of working as a clinical dentist and as a project manager at an oral cancer organisation in India. He has gained further experience in evidence-based researches and data analysis while working with Sheffield city council on “Data Analytics of PROM data on musculoskeletal disorders” and another on “Online gaming and gambling addiction in Sheffield”. He also conducted two independent reviews on “detrimental effect of soft drinks on tooth surface” and “Exposure to high fluoride at early age leads to decrease in IQ level: systematic review with meta-analysis”. Currently, he has four publications and experience of orally presenting his research at national and international conferences.

Jack Hines, Developer (JEH Software)

Jack has a BSc in Economics from Plymouth University. His degree dissertation was a health economic model on the impact of exercise on mortality.

At Crystallise, Jack is developing an online platform with tools to make systematic reviewing faster and more accurate, as well as helping to develop models for mortality, infectious diseases and clinical trial simulations. Now based in Australia, Jack continues to support our internal development of tools aimed at making our process more efficient, accurate and therefore cost-effective.

Dr Robert Challen (Director at Terminological Ltd)

Rob is a former paediatrician who has worked as a health informatician since 2005, including 6 years as head of Health Informatics at the BMJ Group. He founded Terminological in 2016 to develop health informatics, data analytics and clinical research. He is also working towards his PhD on the use of natural language processing and machine learning to derive clinical benefit from electronic patient data.

Rob has worked with Crystallise as a Senior Analyst for 3 years developing mortality models and working on the heoro.com database. Combining approaches from both search engines and terminology indexing, Rob has developed a text indexer within Heoro.com that is capable of finding specific clinical, geographic and patient reported outcome instrument concepts within Medline records. These concepts are exposed as a searchable hierarchical index that allows users to narrow in on their field of interest. The index is manually curated allowing iterative refinement of the terminologies that drive it, delivering a tailored search.

Danielle Bodicoat, Medical statistician (Simplified Data)


Simplified Data is led by Danielle Bodicoat, a former lecturer in epidemiology. She is an experienced medical statistician and medical writer with a solid theoretical grounding. She has a 1st class BSc in Mathematics with Statistics, an MSc in Medical Statistics (Distinction) for which she was awarded a scholarship for by GlaxoSmithKline, and a PhD in Epidemiology. She has over 12 years of applied experience with a proven track record including 80 plus peer-reviewed publications. She has spent years designing, conducting and supervising statistical analyses.

As well as authoring her own papers, she has written and coordinated grant applications that have attracted over £8 million in funding and has also written numerous clinical trial protocols.

JB Medical Ltd (Health Economics and Disease Modelling Consultancy)

JB Medical is a UK-based consultancy that uses the tools of health economics, disease modelling and evidence-based medicine to effectively communicate the roles and benefits of pharmaceuticals and medical devices within a cost-constrained health care environment.

The tension resulting from ever-increasing demands upon healthcare systems to provide access to innovative medicines with finite or diminishing resources has established a mandate for value-based decision making. With strict limitations being placed on manufacturers at both a national and local level, it has never been more important to be able to demonstrate the cost-effectiveness of new treatments. Appropriate research and health economic analysis must be clearly communicated to key purchasers to ensure identification of resources to drive change in clinical practice and so achieve marketing success. JB Medical has the experience and expertise to generate appropriate tools to maximise your success, together with effective communication of the results. Whether your objective is to secure Health Technology Appraisal approval for a new product, to maintain share in a mature market or to survive the transition to a generic environment, we can work with you to identify and deliver optimum marketing strategies.